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High CMRR Instrumentation Amplifier (Schematic and Layout) design for biomedical applications

Instrumentation amplifiers are intended to be used whenever acquisition of a useful signal is difficult. IA’s must have extremely high input impedances because source impedances may be high and/or unbalanced. bias and offset currents are low and relatively stable so that the source impedance need not be constant. Balanced differential inputs are provided so that the signal source may be referenced to any reasonable level independent of the IA output load reference. Common mode rejection, a measure of input balance, is very high so that noise pickup and ground drops, characteristic of remote sensor applications, are minimized.Care is taken to provide high, well characterized stability of critical parameters under varying conditions, such as changing temperatures and supply voltages. Finally, all components that are critical to the performance of the IA are internal to the device. The precision of an IA is provided at the expense of flexibility. By committing to the one specific task of

A Short Review-earlier lesson



    Thomas Edison, famous (at least in America), for inventing the light bulb, See Note 1made many discoveries before he completed his task of lighting the path of the world. Along the way, he incidentally noted that if a filament were energized within a vacuum, that after time, a "shadow" would be left on the inside of the glass, which resembled the shape of the filament. He surmised from this, that within a vacuum, particles (we now call them electrons) were emitted around the wire, forming a cloud, or SPACE CHARGE. This effect became known as the EDISON EFFECT, which is the basic operating theory behind all vacuum tubes.
Later, J. Ambrose Fleming invented the FLEMING VALVE, when he noticed that a second ELEMENT, or ELECTRODE within the vacuum along with the filament, but not touching it, electricity would flow through the vacuum and be collected on the second element. The second element was called a PLATE. He further noted that electricity would flow from the filament to the plate, but not in the opposite direction. The Fleming valve was later dubbed the DIODE, because it has 2 elements inside the vacuum - the filament and the plate.

The AUDION came about when Lee DeForest, In 1906, added a 3rd element between the two. This third element, a control grid, allowed one to electronically control the output of the tube based directly upon the input. This was the birth of Amplification. The term AUDION was later replaced by the term TRIODE, as the tube has 3 elements within the vacuum.

The reason why a tube works is because the CATHODE is heated to a point of THERMONIC EMISSION, forming a SPACE CHARGE or cloud of electrons, which is attracted to the positive charge on the PLATE or ANODE. The Cathode ( K ) of a tube can be either directly or indirectly heated.


Diode tubes only allow electrical current to flow in one direction. By using a diode tube we can change, or RECTIFY, Alternating Current into Direct Current.

An X / Y plot of Voltage vs. Current produces the CHARACTERISTIC CURVE of a device. We looked briefly at the characteristic curve of a DIODE tube. Now let's look, for a moment, at the curve for a resistor.

Remember on page 8, we discussed Ohm's law. We used a 10 Ω resistor for an example. When we applied a 100 volt source to the resistor, 10 Amps would flow through it. What happens, though, if we reduce the voltage to 10 volts?



10 Volts / 10 Ω = Click for Answer



Now let's try another voltage value.

50 Volts / 10 Ω = Click for Answer



Finally, what happens if we apply a Zero volt source to the resistor?

0 Volts / 10 Ω = Click for Answer
If we plot this change on a chart, we will find that a resistor has a characteristic curve which equals a straight line. Not all resistors will be an exact 45� angle. The angle of the line will depend on the value of the resistor. However the characteristic curve of all resistors will be a straight line if plotted voltage vs. current.






Note 1:

Not to incur the wrath of Edison haters or Tesla enthusiests - Tesla is indeed the inventer of many things - including the AC power that the Edison Light bulb presently runs on. However, Tesla did not invent everything, and absolutely did not invent the vacuum tube or light bulb. Of noteworthy mention is the work of Swan in England, upon which many of Edison's experiments were built. In the end - we all build on the work of others, and stand on the shoulders of giants. Tesla was a giant, as was Swan, Edison, Fleming, Deforest, Ohm, and many others, and all built on knowledge obtained through the works of others. Dare I say Newton?


The TRY - ode


Up to now, you have learned something about the diode vacuum tube and how it works. The most important point to rember about the diode is that it only allows current to flow IN ONE DIRECTION.


Thus, when a diode is connected in series with other circuit components, current can flow in only one dirction in all of these components. This characteristic makes the diode a useful device for "rectifying", or converting AC into DC.



You have learned that the diode vacuum tube has only 2 electrodes - a cathode, and a plate (or anode). We briefly hinted that there were other types of tubes tried over the years, with more electrodes added. In 1906, Lee DeForest developed the Audion, later called the Triode because it had 3 electrodes

The third electrode, called the Grid, was placed between the cathode and the plate. The Grid was a piece of wire mesh, coil, perferated metal, or other shape that would allow electrons to pass through it. Physically, the Grid is much closer to the cathode than it is to the plate.

The purpose of the Grid, is to offer a way to control the flow of electrons to the plate. For this reason, the Grid is sometimes referred to as the "Control Grid". Furthermore, in jolly old England - a tube is often referred to as a Valve.

The question you are probably asking at this point is, "How does it work?"

During normal operation, the Plate is kept at a Positive DC potential in relation to the Cathode, so that it always attracts electrons. ( memory note: P = P.... Plate = Positive). The Negative electrons being boiled off the Cathode, are attracted to the Positive plate, and begin to flow in that direction. The more Positive the Plate is, the greater the attraction, and the more electrons flow. We will assume, however, for the sake of our discussion, that we have a fixed high Positive voltage on the plate, and a fixed Negative voltage on the Cathode. We have current flowing from the Cathode to the Plate at a fixed rate.

Now we apply a voltage to the Grid. If we apply a small Positive voltage, electrons flow from the cathode toward the grid. Since the Grid voltage is small, and the Plate voltage is large, the electrons continue past the Grid on to the Plate. The Grid, being closer to the Cathode than the Plate is, gets the electrons moving in the direction of the Plate, and sort of helps them along their way. Because of this, more current flows to the Plate with a Positive Grid than with an un-energized Grid or no Grid at all.

If, however, we apply a Negative voltage to the grid, it creates a Negative field between the Cathode and the Plate. This field restricts the flow of electrons moving to the plate. Sort of like pinching a garden hose. The tighter we pinch it, the less water flow there is. The same is with the Control Grid of an electron tube. The more Negative we swing the grid, the less current flows to (and the fewer electrons fly at) the plate.

So we find, then, that when the Grid Voltage swings Positive, Current flow is increased at the Plate, and when the Grid Voltage swings Negative, the Current flow is decreased at the Plate. Speaking "mathematically", we would say that the "Grid Voltage is directly proportional to the Plate Current ". In plain english, we can say that we can control the CURRENT of the PLATE, by changing the VOLTAGE of the GRID.

So then, what happens when we apply an ALTERNATING current to the grid?

If we place an AC signal on the Control Grid of a triode, the signal swings from Positive, to Negative, then back to Positive. As it does so, the Plate Current swings directly with the Grid Voltage. If we have a fixed resistance load ( a resistor ) across the output of the Plate, we will notice that when the Plate Current goes High, the Plate Voltage goes Low. As the Plate Current goes Low, the Plate Voltage goes High. ( Ohms Law applies ... E=IR ).

So if we compare, when the GRID Voltage swings High.... the PLATE Current swings Low, and by virtue of a fixed output resistance and Ohm's law, the PLATE Voltage also swings Low. The Voltage at the Plate swings OPPOSITE the voltage of the Grid. The Output of the Plate will look like a mirror image of the Input to the Grid.